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Simplified IMP biosynthesis and catabolic pathways in humans. IMP can be synthesized from PRPP by the de novo purine biosynthesis pathway or made from hypoxanthine by the salvage pathway. IMP can be further transformed into AMP and GMP or recycled back by AMP deaminase and GMP reductase. ADSL, adenylosuccinate lyase; GMPS, GMP synthase.
