TABLE 2.
IPA annotation of the top pathways altered by plasma for each incubation time (3-, 6-, and 24-h groups) in HaCaT cells
| Group | Pathway | p value | Ratio | Molecules |
|---|---|---|---|---|
| 3 h | NRF2-mediated oxidative stress response | 7.31E−02 | 12/144 (0.105) | AKR7L, Bach1, CYP2C19, FOS, HMOX1, JUNB/D, MAF, MAFK, MAP3K7, MAPK1, PIK3C2G |
| p38 MAPK signaling | 8.02E−02 | 8/76 (0.105) | DUSP1, HIST2H3C, IL1RAPL1/2, MAP3K7, MEF2C, PLA2G2E, TIFA | |
| PKC signaling | 6.95E−03 | 10/92 (0.109) | CAMK2B/D, CFOS, FYN, HLA-DRB5, MAP3K7/13, MAPK1, NFATC3, PIK3C2G | |
| IL10 signaling | 1.42E−02 | 7/54 (0.13) | FOS, HMOX1, IL1RAAPl1/2, MAP3K7, MAPK1, SOC3 | |
| JAK/STAT signaling | 9.18E−02 | 6/56 (0.107) | FOS, MAPK1, PIK3C2G, SOCS1/3/5 | |
| GM-CSF signaling | 9.18E−02 | 6/57 (0.105) | CAMK2B/D, CSF2, CSF2RA, MAPK1, PIK3C2G | |
| 6 h | MSP-RON signaling pathway | 7.8E−03 | 14/32 (0.438) | ACTA1/2, ATM, CCl2, CSF1, CSF2RB, IL3RA, JAK2, KLK3, PIK3C2G, PIK3R1/3, TLR2/4 |
| 3-Phosphoinositide biosynthesis | 7.65E−03 | 21/67 (0.313) | ASP5, ATM, CDC25C, DUSP1/8, PIK3C2G, PIK3R1/3, PIP5K1B, PAPDC2, PPP1R16/1B, PTEN, PTPN20A/B, PTPRJ, PTPRN, SIRPA, SOC3, TPTE2 | |
| TGF-β signaling | 6.25E−02 | 25/75 (0.333) | ACVR1B, ACVR2A, AMH, BCL2, BMPR2, CDC42, GSC, HNF4A, INHA, JUN, MAPK1, MAPK3, MAPK14, NKX2–5, NODAL, RNF111, RUNX2, SMAD1, SMAD2, SMAD3, SMAD6, SOS2, TGFBR1, ZFYVE9, ZNF423 | |
| 24 h | Neuronal NOS signaling | 1.07E−04 | 4/12 (0.333) | CAMK2, CHRNA1, NOS1, RYR2 |
| γ-Glutamyl cycle | 1.44E−03 | 3/6 (0.5) | GGT1, GGTLC1/2 | |
| MSP-RON pathway | 8.48−E03 | 5/32 (0.156) | CSF1, CSF2RB, PIK3C2G, TLR2/4 |