TABLE 3.
IPA annotation of the top molecular and cellular functions for the action of plasma in HaCaT cells
| Group | Molecular/cellular functions | Ratio | No. | Molecules |
|---|---|---|---|---|
| 3 h | Nucleic acid metabolism | 8.93E−04–3.27E−02 | 13 | AKAP5, CALCA, CRH, GHRH, GHRHR, GLP1R, GLP2R, HMOX1, HTR1A, HTR1B, MRAP, NPPC, RAMP3, TSHR |
| Small molecule biochemistry | 8.93E−04–4.79E−02 | 17 | AKAP5, CALCA, CRH, GHRH, GHRHR, GLP1R, GLP2R, GRM1/5, HMOX1, HTR1A, HTR1B, MRAP, NPPC, RAMP3, TSHR, TSPO, UROC1 | |
| Cell signaling | 3.01E−03–3.27E−02 | 25 | AKAP5, CALCA, CRH, GHRH, GHRHR, GLP1R, HTR1A, HTR1B, KCNH2, MRAP, RAMP3, TSHR | |
| Cellular growth and proliferation | 7.86E−03–1.07E−02 | 16 | AMH, CCL2, CRH, FGFR1, FCER1A, FOS, GHRH, GHRHR, HMOX1, IGFBP5, MAPK1, Nr4A1/3, PPARα, RUNX2, TCF4 | |
| Cellular development | 8.4E−03–1.07E−02 | 15 | AMH, CCL2, CRH, FGFR1, FCER1A, FOS, GHRH, GHRHR, HMOX1, IGFBP5, MAPK1, NR4A1/3, PPARα, TCF4 | |
| 6 h | Nucleic acid metabolism | 1.24E−04–4.13E−02 | 53 | ABCA1, AKAP5, AQP1, CALCA, CRH, CRHR1, CRMP1, CYP3A4, DRD1–4, EIF2AK3, GCG, GLPR1, GPBAR1, HMOX1, HTR1A/B, MTNR1A, NME2, NPY, POMC, PTGER2/3, PTH1R, RAMP1–3, TBXA2R, TSHR |
| Small molecule biochemistry | 1.24E−04–3.71E−02 | 64 | ABCA1, ADCY5, ADM2, AKAP5, CALCA, CRH, CRHR1, DRD1/2/4, GCG, GHRH, GHRHR, GLP1R, GLP2R, GPBAR1, GPR12, HTR1A, HTR1B, MRGPRD, NME2, NPY, OXER1, POMC, PTGER2, PTGER3, PTH1R, RAMP1, RAMP2, RAMP3, TAAR1, TBXA2R, TSHR, … | |
| Cell signaling | 1.18E−03–2.68E−02 | 58 | ABCA1, AKAP5, CALCA, CRH, CRHR1, DRD1/2/4, GCG, GHRH, GHRHR, GLP1R, GPBAR1, HTR1B, NME2, NPY, POMC, PTGER3, PTH1R, RAMP1–3, TBXA2R, TSHR | |
| Cell-to-cell signaling and interaction | 4.13E−03–2.68E−02 | 10 | CNR1, CRH, CRHR1, PSIP1, TGM2, TLR2–5 | |
| Amino acid metabolism | 7.37E−03–3.71E−02 | 9 | DAO, DDC, GAD1, HDC, HNF4A, SDS, TAT, UROC1 | |
| 24 h | Cellular development | 1.66E−03–4.31E−02 | 19 | BAX, CACNA1G, CSF2RB, CTGF, FUT4, FST, IL6, ITGB1, PCYT1B, PRKCA, PTGS2, RYR2, S1PR1/3, SLURP1, TCF4, TLR2/4 |
| Cellular growth and proliferation | 1.66E−03–4.31E−02 | 16 | BAX, CACNA1G, CSF2RB, CTGF, FUT4, FST, IL6, ITGB1, PCYT1B, PRKCA, PTGS2, RYR2, S1PR1/3, SLURP1, TCF4, TLR2/4 | |
| Cell cycle | 1.86E−03–4.31E−02 | 6 | BAX, CDKN2C, IL6, PRKCA/B, PPARα | |
| Cell-to-cell signaling and interaction | 1.86E−03–4.37E−02 | 9 | CSF1, NOS1, KCNH2, SNCA, TLR2/4 | |
| Energy production | 1.86E−03–4.31E−02 | 6 | ADH4, ALDH1A1, HSD17B2, PPARα, SLC16A7, RDH16 |