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. 2015 Jan 25;290(11):6825–6836. doi: 10.1074/jbc.M114.617258

FIGURE 3.

FIGURE 3.

Identification of BDNF-responsive regions in Arc/−1679. A, to identify regions contributing to the transcriptional activation of Arc/−1679, we constructed 5′-deletion mutants of the promoter. Values represent the mean ± S.E. (n = 3–6). **, p < 0.01 versus control (the sample without BDNF). †, p < 0.05 and ††, p < 0.01 versus Arc/−1679 activity in the presence of BDNF. B, basal activity of full length and 5′-deleted Arc promoters. Values represent the mean ± S.E. (n = 3–6). **, p < 0.01 versus Arc/-1679. †, p < 0.05, and ††, p < 0.01. C, fold-induction level of each promoter (Fold-induction) was calculated relative to the basal activity of each promoter. Values represent the mean ± S.E. (n = 3–6). **, p < 0.01 versus Arc/−1679. †, p < 0.05 and ††, p < 0.01. NS: not significant.