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. 2015 Jan 20;290(11):7016–7026. doi: 10.1074/jbc.M114.607952

FIGURE 1.

FIGURE 1.

SK channel expression in control and diabetic mouse atria. A, immunoblots of SK1, SK2, SK3, and GAPDH in homogenates from control and DM mouse atria. B, group data showing significant down-regulation of SK2 and SK3 protein expression in DM, whereas SK1 protein expression was unchanged (n = 3). C, group data showing relative mRNA expression of SK1, SK2, and SK3 in control and DM mouse atria (n = 6). There was no significant difference for SK1 and SK2 between control and DM, but that of SK3 was increased by more than 2-fold in DM. D, immunoblots of Cav1.3, HERG, KCNQ, and Kir6.2 in control and diabetic mouse atria. E, group data showing that the expression of these channels was not altered in DM in contrast to those of SK2 and SK3 channels (n = 7). * represents p < 0.05 versus controls. Error bars represent S.E.