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. 2015 Jan 20;290(11):7016–7026. doi: 10.1074/jbc.M114.607952

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — SK current recordings in atrial myocytes from control and DM mice. A, representative tracings of whole-cell K⁺ currents recorded in freshly isolated atrial myocytes from control (Ctrl) and diabetic mice before (Baseline) and after exposure to apamin (100 pm). B, left panel, the current-voltage relationships of SK currents (defined as K⁺ currents sensitive to 100 pm apamin) showed marked reduction in current densities over a wide range of testing potentials in the diabetic myocytes compared with controls. Right panel, the current-voltage relationship of total K⁺ currents showed a significant decrease of the total outward K⁺ current densities from +10 to −10 mV in diabetic atrial myocytes compared with controls. * represents p < 0.05 versus controls. Error bars represent S.E. pF, picofarad.