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. 2015 Mar 13;6:117. doi: 10.3389/fimmu.2015.00117

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Copyright © 2015 Wang, Hills and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PH domain interactions stabilize Vav1 auto-inhibition in basal state. In the basal state, Vav1 adopts an auto-inhibitory conformation in which the substrate-docking site within the DH domain is blocked by interactions with a helix region from the Ac domain. The interactions between CH, PH, and Ac domains greatly strengthen the auto-inhibitory conformation (left). During T cell activation, phosphorylation of the Ac domain by Lck releases the substrate-docking site and allows GTPase binding (right).