Figure 2.

The Effects of Internal Disordered Segments on Protein Half-Life

(A) Boxplots of protein half-life distributions for different groups of yeast proteins that contain (dark red) or lack (light red) an internal disordered segment (defined as a continuous stretch of ≥40 disordered residues), subclassified based on (B and D) the length of N-terminal disorder (as in Figure 1: long, >30 residues or short, ≤ 30 residues) and (C) the number of internal disordered segments (from zero, top, to three or more, bottom). Each protein is present in only one category per panel. See Figure 1 for further information. See also Figures S2 and S3 and Tables S1 and S4.