Table 2.

Conditional Probabilities for Intrinsically Disordered Segments and Protein Half-Life in Pairs of Paralogs

	Event (E)	Condition (C)	Probability (Event | Condition) = P(E∩C)/P(C)
A	Shorter half-life	divergence of N-terminal disorder	$P\left(\Delta H\mathrm{<}0\min |N_{SL}\right)=\frac{252}{391}=0.64$
	Divergence of N-terminal disorder	shorter half-life	$P\left(N_{SL}|\Delta H\mathrm{<}0\min \right)=\frac{252}{787}=0.32$
B	Shorter half-life	divergence of internal disordered segments	$P\left(\Delta H\mathrm{<}0\min |I_{n\mathrm{\to }n+x}\right)=\frac{323}{561}=0.58$
	Divergence of internal disordered segments	shorter half-life	$P\left(I_{n\mathrm{\to }n+x}|\Delta H\mathrm{<}0\min \right)=\frac{323}{799}=0.40$
C	Shorter half-life	divergence of N-terminal or internal disordered segments	$P\left(\Delta H\mathrm{<}0\min |N_{SL}\mathrm{\cup }{I}_{n\mathrm{\to }n+x}\right)=\frac{542}{741}=0.73$
	Divergence of N-terminal or internal disordered segments	shorter half-life	$P\left(N_{SL}\mathrm{\cup }{I}_{n\mathrm{\to }n+x}|\Delta H\mathrm{<}0\min \right)=\frac{542}{1176}=0.46$
	Shorter half-life	divergence of N-terminal and internal disordered segments	$P\left(\Delta H\mathrm{<}0\min |N_{SL}\mathrm{\cap }{I}_{n\mathrm{\to }n+x}\right)=\frac{33}{211}=0.16$
	Divergence of N-terminal and internal disordered segments	shorter half-life	$P\left(N_{SL}\mathrm{\cap }{I}_{n\mathrm{\to }n+x}|\Delta H\mathrm{<}0\min \right)=\frac{33}{1176}=0.03$
	Divergence of N-terminal and internal disordered segments	longer half-life	$P\left(N_{SL}\mathrm{\cap }{I}_{n\mathrm{\to }n+x}|\Delta H\mathrm{>}0\min \right)=\frac{11}{1013}=0.01$

See Figure 4 for a description of the definitions. N_SL denotes pairs where one paralog has a short and the other paralog a long N-terminal disordered segment. I_{n = > n+x} denotes pairs where one of the two paralogs has a higher number of internal disordered segments (ΔI ≥ 1). See also Tables S8A (for part A) and S8B (for part B).