Supplemental Table II b. Legend for voluntary locomotion dependent variables.

Total distance [The total distance that the subject has traveled. For the purpose of this variable, the location of the subject is defined as the centroid (center of mass) of the subject.]

Horizontal activity count[A count of sensor changes (beam breaks).]

Ambulatory activity count (Number of beam breaks while animal is ambulating. Does not include stereotypy behavior.)

Rest time (The length of time that the subject spent at rest. A resting period is defined as a period of inactivity greater than or equal to 1 second.)

Rest episode count (The total number of resting periods. A resting period is defined as a period of inactivity greater than or equal to 1 second.)

Movement time(The length of time that the subject spent in activity. Activity is defined as a period in which ambulation or stereotypy occurred.)

Movement episode count (The total number of locomotor episodes. Episodes are separated by rest periods of at least 1 second.)

Stereotypy time [The total amount of time that stereotypic behavior is exhibited. A break in stereotypy of 1 second or more is required to separate one stereotypic episode from the next. If the animal breaks the same beam (or set of beams) repeatedly then the monitor considers that the animal is exhibiting stereotypy. This typically happens during grooming, head bobbing, etc.]

Stereotypy episode count [This corresponds to the number of times that stereotypic behavior was observed in the animal. A break in stereotypy of 1 second or more is required to separate one stereotypic episode from the next. If the animal breaks the same beam (or set of beams) repeatedly then the monitor considers that the animal is exhibiting stereotypy. This typically happens during grooming, head bobbing, etc.]

Stereotypy activity count [Number of beam breaks that occur during a period of stereotypic activity. If the animal breaks the same beam (or set of beams) repeatedly then the monitor considers that the animal is exhibiting stereotypy. This typically happens during grooming, head bobbing, etc.]

Vertical episode count (Each time the animal rears up, this is incremented by 1. The animal must go below the level of the vertical sensor for at least 1 second before the next rearing can be registered.)

Vertical activity count (Cumulative vertical beam breaks.)

Vertical activity time (When the animal rears up, this timer starts incrementing.)

Locomotor clockwise revolutions (Counts the number of clockwise revolutions that the subject travels in an open field.)

Locomotor counter-clockwise revolutions (Counts the number of counter- clockwise revolutions that the subject travels in an open field.)