Figure 1.

The expression of ADRB1 was regulated by miRNAs. A. The expression of ADRB1 was up-regulated when AGO2 was knocked down, which means ADRB1 expression was repressed by endogenous microRNAs. B. The schematic diagram of constructing ADRB1 3’UTR reporter vector. C. Dual-luciferase assay to screen miRNAs which may target ADRB1 3’UTR. The results were analyzed by student t-test, and P<0.05 was considered statistically significant *P<0.05, compared with control; **P<0.01, compared with control.