Table 1.
Principle characteristics of the studies included in the meta-analysis
| First author | Year | Country | Ethnicity | Control source | Genotyping method | Case | Control | HWE | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||||||
| Sample size | AA | AG | GG | A | G | Sample size | AA | AG | GG | A | G | |||||||
| Shete (England) | 2009 | America | Caucasian | PB | PCR/MALDI-TOF-MS | 631 | 26 | 179 | 426 | 231 | 1031 | 1433 | 82 | 533 | 818 | 697 | 2169 | 0.69 |
| Shete (America) | 2009 | America | Caucasian | HB | PCR/MALDI-TOF-MS | 1247 | 46 | 405 | 796 | 497 | 1997 | 2235 | 123 | 785 | 1327 | 1031 | 3439 | 0.62 |
| Shete (France) | 2009 | America | Caucasian | PB | PCR/MALDI-TOF-MS | 1332 | 34 | 386 | 912 | 454 | 2210 | 1545 | 59 | 508 | 978 | 626 | 2464 | 0.49 |
| Shete (German) | 2009 | America | Caucasian | PB | PCR/MALDI-TOF-MS | 499 | 16 | 147 | 336 | 179 | 819 | 557 | 28 | 177 | 352 | 233 | 881 | 0.35 |
| Shete (Sweden) | 2009 | America | Caucasian | PB | PCR/MALDI-TOF-MS | 645 | 20 | 195 | 430 | 235 | 1055 | 774 | 54 | 264 | 456 | 372 | 1176 | 0.07 |
| Schoemaker (Denmark) | 2010 | England | Caucasian | PB | PCR | 122 | 1 | 38 | 83 | 40 | 204 | 147 | 8 | 56 | 83 | 72 | 222 | 0.72 |
| Schoemaker (Finland) | 2010 | England | Caucasian | PB | PCR | 95 | 4 | 22 | 69 | 30 | 160 | 96 | 3 | 30 | 63 | 36 | 156 | 0.80 |
| Schoemaker (Sweden) | 2010 | England | Caucasian | PB | PCR | 200 | 4 | 52 | 144 | 60 | 340 | 371 | 25 | 116 | 230 | 166 | 576 | 0.05 |
| Schoemaker (UK-North) | 2010 | England | Caucasian | PB | PCR | 376 | 18 | 106 | 252 | 142 | 610 | 632 | 44 | 212 | 376 | 300 | 964 | 0.07 |
| Schoemaker (UK-South) | 2010 | England | Caucasian | PB | PCR | 232 | 8 | 65 | 159 | 81 | 383 | 390 | 28 | 129 | 233 | 185 | 595 | 0.09 |
| Chen | 2011 | China | Asian | HBl | MassARRAY | 958 | 411 | 454 | 93 | 1276 | 640 | 1040 | 547 | 438 | 55 | 1532 | 548 | 0.01 |
| Wang | 2011 | America | Caucasian | Mixed | HumanHap | 332 | 15 | 99 | 218 | 129 | 535 | 817 | 49 | 296 | 472 | 394 | 1240 | 0.77 |
| Li | 2013 | China | Asian | PB | MassARRAY | 629 | 293 | 261 | 75 | 847 | 411 | 644 | 337 | 267 | 40 | 941 | 347 | 0.18 |
| Safaeian (NCI) | 2013 | America | Caucasian | PB | HumanHap | 322 | 11 | 93 | 218 | 115 | 529 | 385 | 20 | 134 | 231 | 174 | 596 | 0.92 |
| Safaeian (NIOSH) | 2013 | America | Caucasian | PB | HumanHap | 300 | 12 | 106 | 182 | 130 | 470 | 539 | 25 | 175 | 339 | 225 | 853 | 0.69 |
| Safaeian (PLCO) | 2013 | America | Caucasian | PB | HumanHap | 133 | 0 | 29 | 104 | 29 | 237 | 855 | 51 | 323 | 481 | 425 | 1285 | 0.74 |
| Safaeian (ATBC) | 2013 | Finland | Caucasian | PB | HumanHap | 37 | 1 | 11 | 25 | 13 | 61 | 1269 | 51 | 374 | 844 | 476 | 2062 | 0.24 |
| Safaeian (AHS) | 2013 | America | Caucasian | PB | HumanHap | 18 | 2 | 6 | 10 | 10 | 26 | 35 | 1 | 8 | 26 | 10 | 60 | 0.69 |
| Jin | 2013 | China | Asian | PB | MassARRAY | 433 | 48 | 181 | 204 | 277 | 589 | 462 | 24 | 202 | 236 | 250 | 674 | 0.02 |
PCR: polymerase chain reaction; MALDI-TOF: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; TaqMan: TaqManSNP; NCI: the National Cancer Institute; NIOSH: the National Institute for Occupational Safety and Health; PLCO: the Prostate, Lung, Colorectal and Ovarian; ATBC: the Alpha-Tocopherol, Beta-Carotene; AHS: the Agricultural Health Study; HWE: Hardy-Weinberg equilibrium.