Table 2.
Summary ORs of MGMT polymorphisms and CRC risk
| Analysis | Case/control | Homozygote model | Dominant model | Recessive model | Allele model | Heterozygote model | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| OR (95% CI) | PHet | OR (95% CI) | PHet | OR (95% CI) | PHet | OR (95% CI) | PHet | OR (95% CI) | PHet | ||
| Leu84Phe | |||||||||||
| All | 1565/4589 | 1.46 (0.93, 2.27) | 0.371 | 0.89 (0.77, 1.04) | 0.087 | 1.54 (0.99, 2.40) | 0.347 | 0.95 (0.84, 1.09) | 0.352 | 0.87 (0.68, 1.10) | 0.048 |
| Ethnicity | |||||||||||
| Caucasian | 1273/3423 | 1.70 (1.06, 2.72) | 0.691 | 0.93 (0.78, 1.10) | 0.071 | 1.80 (1.12, 2.87) | 0.660 | 1.00 (0.87, 1.15) | 0.534 | 0.89 (0.66, 1.20) | 0.027 |
| Asian | 292/1166 | 0.29 (0.04, 2.26) | / | 0.76 (0.53, 1.09) | / | 0.30 (0.04, 2.34) | / | 0.74 (0.53, 1.05) | / | 0.79 (0.55, 1.14) | / |
| Ile143Val | |||||||||||
| All | 1282/6089 | 1.07 (0.60, 1.91) | 0.171 | 1.00 (0.71, 1.41) | 0.002 | 1.10 (0.61, 1.96) | 0.188 | 1.00 (0.73, 1.38) | 0.001 | 1.00 (0.73, 1.37) | 0.008 |