Table 2.
Determination of the genetic effect of ACE I/D polymorphism on diabetic peripheral neuropathy and subgroup analysis
| Comparison | Study | Sample size | No. of studies | Test of association | Model | Heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| case | control | OR (95% CI) | Z | P Value | χ2 | P Value | I2 (%) | ||||
| DD vs. II | Overall | 336 | 637 | 5 | 1.57 (1.15-2.14) | 2.83 | 0.005 | R | 4.29 | 0.37 | 7 |
| ID vs. II | Overall | 502 | 910 | 5 | 1.68 (1.28-2.19) | 3.78 | 0.0002 | R | 4.22 | 0.38 | 5 |
| DD vs. ID | Overall | 558 | 907 | 5 | 0.99 (0.79-1.25) | 0.04 | 0.97 | R | 3.42 | 0.49 | 0 |
| DD+ID vs. II | Overall | 1430 | 1873 | 8 | 1.25 (1.05-1.48) | 2.58 | 0.01 | R | 5.58 | 0.59 | 0 |
| DD+ID vs. II | Caucasian | 1367 | 1852 | 7 | 1.24 (1.05-1.47) | 2.49 | 0.01 | R | 4.53 | 0.61 | 0 |
vs., versus; R, random-effects model.