Table 3.
Comparison of median survival time stratified by potential factors
| Stratification | Median survival time (95% CI) | P | Stratification | Median survival time (95% CI) | P |
|---|---|---|---|---|---|
| Portal vein tumor thrombi | Abdominal dropsy | ||||
| Yes vs. No | 8.0 (6.0 ~ 10.0) VS. 22.0 (9.0 ~ 38.0) | 0.001 | Presence vs. Absence | 7.0 (3.0 ~ 13.0) VS. 11.5 (8.0 ~ 22.0) | 0.078 |
| Pulmonary metastasis size | AFP level | ||||
| < 2 vs. ≥ 2 cm | 8.0 (6.0 ~ 30.0) VS. 13.0 (10.0 ~ 22.0) | 0.830 | < 100 vs. ≥ 100 ng/ml | 12.0 (6.0 ~ 22.0) VS. 10.0 (5.0 ~ 24.0) | 0.726 |
| Gender | Liver lesion size | ||||
| Male vs. Female | 10.0 (8.0 ~ 20.0) VS. 11.0 (5.0 ~ 30.0) | 0.537 | < 10 vs. ≥ 10 cm | 12.0 (6.0~20.0) VS. 10.0 (7.0 ~ 22.0) | 0.801 |
| Age | Intrahepatic tumors | ||||
| ≤ 50 vs. > 50 | 10.5 (7.0 ~ 13.0) VS. 12.0 (3.0 ~ 38.0) | 0.570 | Solitary vs. Multiple | 9.0 (5.0 ~ 14.0) VS. 11.0 (7.0 ~ 24.0) | 0.447 |
| Cause of HCC | Pulmonary metastases | ||||
| HBV vs. Non-HBC | 10.5 (8.0 ~ 20.0) VS. 9.5 (5.0 ~ 40.0) | 0.734 | Solitary vs. Multiple | 14.0 (7.0 ~ 38.0) VS. 10.0 (6.0 ~ 13.0) | 0.378 |
| Child-pugh classification | Intrahepatic tumor response | ||||
| Grade A vs. Grade B | 12.0 (7.0 ~ 22.0) VS. 8.0 (3.0 ~ 13.0) | 0.150 | CR + PR VS. SD + PD | 17.0 (10.0 ~ 30.0) VS. 6.5 (3.0 ~ 9.0) | < 0.001 |
Note: AFP, alpha fetoprotein; ECOG, Eastern Cooperative Oncology Group; CR (Complete Response) represents the complete disappearance of all target lesions; PR (Partial Response) means 30% decrease in the longest diameter of target lesions; PD (Progressive Disease) corresponds to at least 20% increase in the longest diameter of target lesions; SD (Stable Disease) indicates neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD.