Table 3.
XPC genotypes and the levels of AFB1-DNA adducts
| XPC genotype | Low-level adducts (n = 1537) | High-level adducts (n = 1021) | OR (95% CI)a | P | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| n | % | n | % | |||
| LL | 700 | 45.5 | 369 | 36.1 | 1 | |
| LG | 699 | 43.5 | 478 | 46.8 | 1.37 (1.15-1.63) | 3.74 × 10-4 |
| GG | 168 | 10.9 | 174 | 17.0 | 1.99 (1.55-2.55) | 5.62 × 10-8 |
| LG/GG | 837 | 54.5 | 654 | 63.9 | 1.49 (1.27-1.76) | 1.00 × 10-6 |
a
Adjusted for age, sex, ethnicity, HBsAg, and anti-HCV.
Abbreviations: LL, XPC genotype with codon 939 Lys alleles; LG, XPC genotype with codon 939 Lys and Gln alleles; GG, XPC genotype with codon 939 Gln alleles; LG/GG, the combination of LG and GG genotypes.