Table 5.
Joint effects of XPC polymorphism and AFB1-exposure years on AFB1-DNA adducts
| AFB1-exposure years | XPC genotype | Low-level adducts | High-level adducts | OR (95% CI)a | P | ||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| n | % | n | % | ||||
| Short | LL | 387 | 25.2 | 180 | 17.6 | Reference | |
| LG | 388 | 25.2 | 228 | 22.3 | 1.26 (0.99-1.61) | 0.06 | |
| GG | 96 | 6.2 | 80 | 7.8 | 1.81 (1.28-2.56) | 7.89 × 10-4 | |
| LG/GG | 484 | 31.5 | 308 | 30.2 | 1.37 (1.09-1.72) | 6.59 × 10-3 | |
| Long | LL | 313 | 20.4 | 189 | 18.5 | 1.30 (1.01-1.68) | 0.04 |
| LG | 281 | 18.3 | 250 | 24.5 | 1.94 (1.52-2.49) | 1.29 × 10-7 | |
| GG | 72 | 4.7 | 94 | 9.2 | 2.87 (2.01-4.09) | 6.64 × 10-9 | |
| LG/GG | 353 | 23.0 | 344 | 33.7 | 2.13 (1.69-2.69) | 1.69 × 10-10 | |
a
Adjusted for age, sex, HBsAg, anti-HCV, and race.
Abbreviations: LL, XPC genotype with codon 939 Lys alleles; LG, XPC genotype with codon 939 Lys and Gln alleles; GG, XPC genotype with codon 939 Gln alleles; LG/GG, the combination of LG and GG genotypes.