Table 3. Known antibiotic resistance determinants in sample set.
Gene name | FA1090 Reference locus_tag/ Gene Bank ID |
Genetic Mutations | Resistance Phenotype | References |
---|---|---|---|---|
mtrR | NGO1366 | G45D, A39T (glycine and aspartate substitutions) | Decreased susceptibility to macrolides and beta-lactams | PMID: 18761689 |
mtrCDE promoter | NGO1366 | Single nucleotide deletion on reference genome position 1327932 | Decreased susceptibility to macrolides and beta-lactams | PMID: 18761689 |
penB | NGO1812 | G101K, A102D (glycine and alanine substitutions) | Decreased susceptibility to third-generation cephalosporins | PMID: 17420216 |
Mosaic penA | NGO1542 | Mosaic pattern amino acid substitutions form position 294 to end of gene | Decreased susceptibility to third-generation cephalosporins | PMID: 20028823 |
rpsJ | NGO1841 | V57M | Decreased susceptibility to tetracycline | PMID:16189114 |
23S rRNA | AF450080 | C2611T (Cystine to Threonine substitution) | Decreased susceptibility to Azithromycin | PMID: 12183262 |
tetM | N/A | Horizontally transferred determinant on plasmids | Resistance to tetracycline(MIC > = 16 µg/ml) | PMID: 21349987 |