Table 3. Known antibiotic resistance determinants in sample set.

The description includes the PubMed reference ID and associated resistance phenotypes of these determinants in N. gonorrhoeae. Cephalosporin antibiotics include cefixime and ceftriaxone, while macrolides include erythromycin and azithromycin.

Gene name	FA1090 Reference locus_tag/ Gene Bank ID	Genetic Mutations	Resistance Phenotype	References
mtrR	NGO1366	G45D, A39T (glycine and aspartate substitutions)	Decreased susceptibility to macrolides and beta-lactams	PMID: 18761689
mtrCDE promoter	NGO1366	Single nucleotide deletion on reference genome position 1327932	Decreased susceptibility to macrolides and beta-lactams	PMID: 18761689
penB	NGO1812	G101K, A102D (glycine and alanine substitutions)	Decreased susceptibility to third-generation cephalosporins	PMID: 17420216
Mosaic penA	NGO1542	Mosaic pattern amino acid substitutions form position 294 to end of gene	Decreased susceptibility to third-generation cephalosporins	PMID: 20028823
rpsJ	NGO1841	V57M	Decreased susceptibility to tetracycline	PMID:16189114
23S rRNA	AF450080	C2611T (Cystine to Threonine substitution)	Decreased susceptibility to Azithromycin	PMID: 12183262
tetM	N/A	Horizontally transferred determinant on plasmids	Resistance to tetracycline(MIC > = 16 µg/ml)	PMID: 21349987