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. 2015 Feb 19;11(2):789. doi: 10.15252/msb.20145664

Figure 5. SYK kinase activity is specifically required in basal-like breast cancer cell lines.

Figure 5

  • A Cell line panel of basal-like (n = 9) and luminal cells (n = 10) treated with two SYK inhibitors. P < 0.0001 for R406 and P < 0.01 for BAY61-6306, Mann–Whitney U-test.
  • B Dose–response experiment with the SYK inhibitor BAY61-3606 on TGF-β- or vehicle-treated MMEC-HRASV12G cells. Data are expressed as mean ± SD, n = 3.
  • C Cells as in (B) treated with the SYK inhibitor R406. Data are expressed as mean ± SD, n = 3.
  • D MDA-MB-468 transfected with a SYK cDNA or GFP-expressing vector were treated with 10 μM BAY61-3606 for 7 days. Cells were visualized using crystal violet.