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. 2015 Jan 20;593(Pt 5):1083–1111. doi: 10.1113/jphysiol.2014.279232

Figure 1.

Figure 1

Illustration of classical and inverse metamodelling for sensitivity analysis and parameter estimation

Classical metamodelling was used for sensitivity analysis of the Land model (Land et al. 2012a) and the Niederer model (Niederer et al. 2006), using the regression coefficients as sensitivity measures (Tøndel et al. 2014). The inverse metamodelling was included in the parameter fitting pipeline shown in Fig. 2. The figure is reproduced from Tøndel et al. (2014) with permission from BioMed Central.