Table 1.

Initial ranges for the Land model parameters used in the model parameterisation

			Fitting to mouse data		Fitting to rat and human data
		Parameter set
		from original	Minimum	Maximum	Minimum	Maximum
Parameter	Description	publication	value	value	value	value
Tref	Reference tension (kPa)	120	100	140	90	140
Ca50ref	Calcium sensitivity at resting sarcomere length (μm)	0.6–0.8	0.5	0.8	0.5	2
TRPN50	Troponin C sensitivity	0.35	0.25	0.5	0.3	0.5
nTRPN	Hill coefficient for cooperative binding of Ca2+ to TnC	2	1	2.5	1	2
kTRPN	Unbinding rate of Ca2+ from TnC (ms−1)	0.1	0	0.5	0.05	0.4
nxb	Hill coefficient for cooperative crossbridge action	5	3	7	2	7
kxb	Scaling factor for the rate of crossbridge binding (ms−1)	0.1	0	0.6	0	0.1
β1	Magnitude of length-dependent activation effects	−1.5	−2	−1	−1.5*	−1.5*
β0	Magnitude of filament overlap effects	1.65	1	5	1.65*	1.65*

^*β₁ and β₀ were not varied in the model parameterisation to rat and human data, as only resting sarcomere length was used.