Table 7.
Mean ± SD for the Niederer model parameters giving mouse, rat and human output metric values
| Mouse data | Rat data | Human data | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Using the | |||||||||
| Using the | Grandi– | ||||||||
| Using the | Using | Using the | Using | Beuckel- | Using | Pasqualini– | Using the | Using the | |
| measured | synthetic Ca | measured Ca | synthetic | mann Ca | synthetic | Bers Ca | Ten Tusscher | O'Hara–Rudy | |
| Ca transient | transients | transient | Ca transients | transient | Ca transients | transient | Ca transient | Ca transient | |
| Parameter | (n = 7*) | (n = 3) | (n = 63) | (n = 46) | (n = 52) | (n = 31) | (n = 6) | (n = 99) | (n = 122) |
| Ca50ref | 0.34×10–3 ± | 0.34×10–3 ± | 1.89×10–3 ± | 1.78×10–3 ± | 1.11×10–3 ± | 1.60×10–3 ± | 1.1×10–3 ± | 2.0×10–3 ± | 0.93×10–3 ± |
| 2.03×10–5 | 2.4×10–5 | 3.4×10–4 | 3.79×10–4 | 1.57×10–4 | 2.53×10–4 | 4.0×10–4 | 6.4×10–5 | 6.2×10–5 | |
| krefoff | 0.11 ± 0.03 | 0.07 ± 0.01 | 0.13 ± 0.05 | 0.17 ± 0.09 | 0.28 ± 0.08 | 0.21 ± 0.03 | 0.17 ± 0.07 | 0.11 ± 3.2×10–3 | 0.29 ± 0.04 |
| kon | 230.10 ± 44.80 | 234.20 ± 34.90 | 194.6 ± 95.4 | 188.0 ± 91.9 | 271.1 ± 130.6 | 330.1 ± 113.2 | 299.9 ± 79.3 | 212.0 ± 6.20 | 240.9 ± 73.5 |
| nr | 1.78 ± 0.33 | 1.64 ± 0.81 | — | — | — | — | — | — | — |
| β0 | 0.40 ± 0.36 | 0.60 ± 0.52 | — | — | — | — | — | — | — |
| β1 | −1.30 ± 0.10 | −1.50 ± 0.26 | — | — | — | — | — | — | — |
| γ | 4.39 ± 0.40 | 3.82 ± 0.98 | 2.14 ± 0.40 | 2.75 ± 1.29 | 2.46 ± 0.82 | 1.68 ± 0.52 | 1.08 ± 0.05 | 1.02 ± 0.01 | 1.74 ± 0.26 |
| nH | 12.22 ± 1.34 | 14.05 ± 0.92 | 7.74 ± 2.18 | 8.27 ± 3.35 | 10.08 ± 2.07 | 11.22 ± 2.21 | 6.17 ± 1.60 | 7.32 ± 0.21 | 13.66 ± 0.80 |
| Tref | 122.00 ± 11.20 | 115.30 ± 13.00 | 111.7 ± 14.2 | 112.0 ± 15.2 | 118.9 ± 12.8 | 119.2 ± 13.2 | 107.0 ± 17.0 | 92.2 ± 1.79 | 104.2 ± 7.98 |
| α0 | 0.04 ± 0.01 | 0.04 ± 0.02 | 0.08 ± 0.04 | 0.12 ± 0.09 | 0.26 ± 0.11 | 0.31 ± 0.06 | 0.41 ± 0.12 | 0.08 ± 2.4×10–3 | 0.28 ± 0.03 |
| αr1 | 0.38 ± 0.08 | 0.37 ± 0.11 | 0.11 ± 0.04 | 0.16 ± 0.09 | 0.05 ± 0.01 | 0.07 ± 0.02 | 0.01 ± 2.2×10–3 | 0.01 ± 3.6×10–4 | 0.01 ± 9.0×10–4 |
| αr2 | 0.01 ± 0.01 | 4.3×10–3 ± 6.0×10–3 | — | — | — | — | — | — | — |
| Kz | 0.07 ± 0.03 | 0.09 ± 0.04 | — | — | — | — | — | — | — |
| Cad | —† | 0.22 ± 0.03 | — | 0.24 ± 0.07 | — | 103.2 ± 24.4 | — | — | — |
| Camax | — | 0.51 ± 0.03 | — | 1.73 ± 0.32 | — | 869.0 ± 92.2 | — | — | — |
| τCa1 | — | 21.15 ± 0.81 | — | 26.45 ± 1.46 | — | 120.2 ± 7.4 | — | — | — |
| τCa2 | — | 21.15 ± 0.81 | — | 26.45 ± 1.46 | — | 232.7 ± 13.3 | — | — | — |
*
n denotes the number of succeeding parameter sets. †The parameters for which no results are given were not varied in the respective parameter fittings. The parameters β0 and β1 were not varied for rat and human, as only resting sarcomere length was used. Ca transient parameters are not given where the measured or fixed Ca transients were used.