Table 2.
Plasma concentrations of CRP, pro-inflammatory chemokines and markers of endothelial inflammation
| Control | CRP + | |||||
|---|---|---|---|---|---|---|
| Week 0 | Week 8 | Week 0 | Week 6 | Week 8 | ||
| CRP | (mg ml−1) | 0.6 ± 0.1 | 0.8 ± 0.3 | 3.5 ± 0.7* | 2.5 ± 0.3* | 2.5 ± 0.5* |
| IL-1β | (ng ml−1) | 7.6 ± 1.1 | 7.6 ± 0.7 | 6.8 ± 0.7 | 6.4 ± 0.4 | 6.2 ± 0.3 |
| IL-6 | (ng ml−1) | 8.1 ± 1.1 | 8.5 ± 1.0 | 8.3 ± 0.8 | 8.1 ± 0.3 | 9.5 ± 0.5 |
| IL-8 | (ng ml−1) | 21.9 ± 7.3 | 21.6 ± 3.7 | 17.5 ± 3.0 | 16.7 ± 1.3 | 18.2 ± 0.9 |
| IL-10 | (ng ml−1) | 10.1 ± 2.0 | 9.4 ± 1.0 | 13.4 ± 3.9 | 8.1 ± 0.4 | 9.5 ± 2.4 |
| IL-12 | (ng ml−1) | 22.5 ± 4.6 | 18.4 ± 2.4 | 23.4 ± 9.9 | 17.1 ± 3.1 | 22.5 ± 5.5 |
| GM-CSF | (ng ml−1) | 16.9 ± 5.9 | 15.4 ± 3.2 | 12.1 ± 4.1 | 11.4 ± 1.3 | 13.1 ± 2.1 |
| MCP-1 | (ng ml−1) | 55.9 ± 9.4 | 54.8 ± 5.8 | 56.2 ± 3.3 | 60.9 ± 6.6 | 58.4 ± 5.7 |
| TNFα | (ng ml−1) | 27.5 ± 4.1 | 28.7 ± 3.0 | 23.3 ± 3.4 | 25.4 ± 3.9 | 24.0 ± 1.0 |
| ICAM-1 | (ng ml−1) | 150 ± 23 | 137 ± 22 | 141 ± 15 | 144 ± 16 | 145 ± 10 |
| E-selectin | (ng ml−1) | 43.8 ± 3.7 | 41.3 ± 3.5 | 43.0 ± 7.0 | 40.7 ± 5.3 | 39.3 ± 4.4 |
| P-selectin | (ng ml−1) | 43.6 ± 3.2 | 42.8 ± 2.4 | 45.0 ± 2.3 | 47.1 ± 3.4 | 47.2 ± 4.4 |
| VCAM-1 | (ng ml−1) | 722 ± 44 | 750 ± 69 | 692 ± 60 | 670 ± 87 | 620 ± 59 |
Data are the mean ± SEM; n = 10 for control group and n = 6 for CRP+ group. Statistical evaluation of data was performed by non-parametric tests. When significant, the Mann–Whitney test was used for post hoc analysis.*P < 0.05 vs. control group.GM-CSF, granulocyte-macrophage colony-stimulating factor; ICAM-1, intercellular adhesion molecule ; VCAM-1, vascular cell adhesion molecule-1.