Table 3.
Relative metabolite levels measured by 1H NMR of fecal water extracts from obese children with NAFLD, obese children without evidence of NAFLD and normal healthy children. Values are Mean ± SE of integrated signal intensities (arbitrary units) normalized to TSP standard.
| METABOLITE | Healthy | Obese with NAFLD | Obese without evidence of NAFLD |
|---|---|---|---|
| (n = 22) | (n = 11) | (n = 6) | |
| Ethanol | 15.3 ± 4.1a | 32.1 ± 9.8b | 12.4 ± 4.2ab |
| Uracil | 7.2 ± 0.8 | 6.1 ± 1.6 | 8.9 ± 1.8 |
| Acetate | 550.0 ± 47.1a | 417.9 ± 44.7b | 497.5 ± 95.8ab |
| Formate | 7.0 ± 0.5a | 4.2 ± 1.1b | 7.0 ± 1.0ab |
| Glucose | 17.8 ± 5.1 | 23.4 ± 3.0 | 27.4 ± 7.6 |
| Fumarate | 1.4 ± 0.2 | 1.4 ± 0.5 | 1.6 ± 0.5 |
| Lactate | 17.9 ± 2.7 | 11.7 ± 2.3 | 15.1 ± 1.6 |
| Alanine | 34.9 ± 5.2ab | 27.0 ± 3.9a | 42.9 ± 8.1ab |
| Butyrate | 221.0 ± 30.5 | 226.0 ± 36.8 | 260.1 ± 75.9 |
| Proprionate | 250.2 ± 30.9 | 227.3 ± 44.0 | 249.3 ± 45.4 |
| Valerate | 19.9 ± 3.0a | 9.9 ± 2.3b | 12.2 ± 2.2ab |
| Lysine | 44.3 ± 8.1a | 62.8 ± 16.1ab | 81.7 ± 29.6b |
Across rows, different superscript letters indicate means that are significantly different (P < 0.05) using analysis of variance (ANOVA) with Bonferroni correction.