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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: Wiley Interdiscip Rev Membr Transp Signal. 2012 Aug 9;1(6):789–803. doi: 10.1002/wmts.62

Figure 1.

Figure 1

Model of cytoskeletal signaling by the P2Y2 receptor through Go and G12 proteins. The P2Y2 receptor, which is linked to the actin cytoskeleton through association with filamin A,67 initiates cytoskeletal rearrangements involved in cell migration, neurite extension and phagocytosis by promoting the growth of actin filaments near the activated receptor. This is accomplished, in part, by the interaction of the P2Y2 receptor RGD domain with αVβ3/5 integrins.50 Integrin interaction allows the P2Y2 receptor to access and activate Go and G12 proteins that are known to associate with β3 integrins and with the integrin-associated protein, CD47.49,50 Activation of Go and G12 leads to activation of Rac1 and RhoA, which then activate the actin-binding LIM kinases (LIMKs) responsible for serine-phosphorylation/deactivation of the actin disassembly protein, cofilin.48,49