. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Pharmacogenomics. 2015;16(3):273–285. doi: 10.2217/pgs.14.170

Table 1.

Examples of in vitro human cell line model systems that have been used in cancer pharmacogenomic studies.

In vitro human cell line model		Genetic variation
Immortalized cell lines
EBV-transformed LCLs	Human Variation Panel	Germline
EBV-transformed LCLs	HapMap LCLs	Germline

Cancer cell lines
Heterogeneous panels	NCI-60 panel	Germline and somatic
	CCLE	Germline and somatic
	CGP	Germline and somatic
	GSK cancer cell line panel	Germline and somatic
Homogeneous panels	Breast cancer cell line panel	Germline and somatic
Homogeneous panels	Colorectal cancer cell line panel	Germline and somatic
Isogenic cancer cell lines		Germline and somatic

CCLE: Cancer cell line encyclopedia; CGP: Cancer genome project; EBV: Epstein-Barr virus; LCL: Lymphoblastoid cell line.