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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: J Med Chem. 2011 Dec 7;55(1):437–448. doi: 10.1021/jm2013198

Scheme 2. a.

Scheme 2. a

aReaction conditions: (a) DMF, pyridine, 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (1.1 equiv), room temp 10 min; (b) bis(tri-n-butylammonium)pyrophosphate (1.1 equiv), tri-n-butylamine (4 equiv), room temp 10 min; (c) BH3·SMe2, room temp 15 min; (d) NMP, MgCl2, room temp 16 h; (e) pH 2.3, room temp 3 h; pH 9, room temp 40 min.