Table 2.

Top pathways, functions, and networks identified Ingenuity Pathways Analysis of the genes differentially expressed (DE) between 2-hour post-exercise and immediate post-exercise blood samples. Canonical pathways are known pathways for which there is a significant association with the molecules in the data set. Biological functions are composed of the molecules in the data set that are know to be involved in various diseases and functions, and are further divided statistical significance subcategories.

Canonical pathways	P-value	Number of differentially expressed molecules to total in pathway
Natural Killer Cell Signaling	1.6 × 10-7	20/115 (17.4%)
NF-kB Signaling	8.9 × 10-5	17/149 (11.4%)
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells	3.7 × 10-4	7/31 (22.6%)
T Cell Receptor Signaling	9.9 × 10-4	13/110 (11.8%)
Communication between Innate and Adaptive Immune Cells	1.6 × 10-3	10/90 (11.1%)
Biological functions	P-value	Number of differentially expressed molecules
Inflammatory Response	≤ 5.8 × 10-3	132
Infectious Disease	≤ 8.0 × 10-3	100
Respiratory Disease	≤ 8.0 × 10-3	74
Inflammatory Disease	≤ 7.3 × 10-3	193
Immunological Disease	≤ 8.0 × 10-3	187
Antigen Presentation	≤ 6.6 × 10-3	125
Cell-To-Cell Signaling and Interaction	≤ 8.0 × 10-3	140
Cell-mediated Immune Response	≤ 8.0 × 10-3	139
Humoral Immune Response	≤ 5.4 × 10-3	122
Hematological System Development and Function	≤ 5.4 × 10-3	134
Immune Cell Trafficking	.≤ 7.4 × 10-3	88