Skip to main content
. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3305–3319. doi: 10.1021/jm100030u

Figure 3.

Figure 3

Rates of hydrolysis of analogues 9 and 10B at pH 1.4 at 37 °C, as monitored by HPLC. Hydrolysis of 7.5 mM analogue 9 or 10B in KCl/HCl buffer at pH 1.4 and 37 °C was recorded for 5 days at 7–17 h intervals. (A) HPLC chromatograms of analogue 9 and hydrolysates at t = 6, 52, 216 h. (B) Kinetics of acidic hydrolysis of analogue 9 (t1/2 = 65 h) and time-dependent formation of degradation products. (C) Kinetics of acidic hydrolysis of analogue 10B (t1/2 = 8 h).