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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Toxicol Pathol. 2014 May 28;43(2):145–170. doi: 10.1177/0192623314532036

Figure 6.

Figure 6

A and B: The IDPs are early lesions that represent the transition between the normal TEB and carcinoma in situ. C and D: IDPs appear to evolve into carcinoma in situ through the development of: (a) micropapillae, which might be the only pattern present or combined with cribriform pattern; (b) pseudolumina, forming a cribriform pattern, or (c) a comedo pattern. A progressively increasing desmoplastic reaction in the stroma surrounding the transformed ductal structures is a hallmark of neoplastic progression. Stained with H&E, ×20.