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. Author manuscript; available in PMC: 2015 Apr 10.
Published in final edited form as: Nat Commun. 2014 Apr 10;5:3614. doi: 10.1038/ncomms4614

Figure 2. Receptor-binding site recognition by F045-092 to Vic1975/H3 in comparison to the α2,6 sialoglycan receptor.

Figure 2

(a) F045-092 inserts its HCDR3 into the HA receptor-binding site. The carboxylate side chain of F045-092 Asp100e overlaps with the (b) carboxylate moiety of the sialic acid of the α2,6 sialoglycan receptor (PDB 2YP4) and uses identical hydrogen bonding interactions, which are shown as black dashed lines. An additional hydrogen bond between the main chains of F045-092 and HA is circled in red dashed lines. The Leu100d side chain of F045-092 overlaps with the acetamide moiety of sialic acid.