Skip to main content
. Author manuscript; available in PMC: 2015 Apr 10.
Published in final edited form as: Nat Commun. 2014 Apr 10;5:3614. doi: 10.1038/ncomms4614

Figure 3. Sequence conservation of the F045-092 epitope across human H3 viruses.

Figure 3

(a) The F045-092 contact residues on HA are depicted as sticks. The percent conservation for the most common residue found in the H3 subtype is labeled, which is not always identical to the residue at that position in the Vic1975/H3 sequence. (b) Interaction of F045-092 with Vic1975/H3 illustrating the sequence conservation of neutralizing epitope on the HA surface. For identification of the HA residues and positions that are color coded on the surface, see (a). The F045-092 contact residues are labeled, colored by HCDR, and shown as sticks. (c) Percent identity of the most common residue among human H3 isolates plotted against the linear sequence of HA. Residues contacted by F045-092 or CR9114 are indicated by red or green diamonds, respectively. Although F045-092 contacts more hypervariable residues than CR9114, it can still broadly neutralize the H3 subtype.