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. Author manuscript; available in PMC: 2015 Apr 10.
Published in final edited form as: Nat Commun. 2014 Apr 10;5:3614. doi: 10.1038/ncomms4614

Figure 5. Common trends in recognition of the HA by receptor-binding site targeted antibodies.

Figure 5

(a) Antibodies HC19 (red, PDB 2VIR), HC63 (light blue, PDB 1KEN), CH65 (green, PDB 3SM5), and 5J8 (orange, PDB 4M5Z) use an Asp residue to insert a carboxylate in the receptor-binding site that would be occupied by the carboxylate of sialic acid of the α2,6 sialoglycan receptor (dashed red circle). (b) Antibodies HC19 (red, PDB 2VIR), C05 (yellow, PDB 4FP8), 8F8 (blue, PDB 4HF5), 8M2 (pink, PDB 4HFU), and 2G1 (green, PDB 4HG4) use hydrophobic residues to target the receptor-binding site that would be occupied by the acetamide moiety of sialic acid (dashed blue circle). The disulfide loop of the F045-092 HCDR3 is shown and colored purple.