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. 2013 Oct 9;70:326–340. doi: 10.1016/j.ejmech.2013.09.047

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Copyright © 2013 Elsevier Masson SAS. All rights reserved.

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Scheme 1 — Putative bioactivation pathway of diamidate prodrugs: a) enzyme-mediated ester hydrolysis; b) spontaneous intracellular displacement; c) spontaneous hydrolysis; d) enzyme-mediated P–N bond cleavage.