Table 3.
HCV replicon assays (type 1b) in Huh 7 cells.
| Compd | Nucleoside | AA | R | EC50 (μM) | CC50 (μM) |
|---|---|---|---|---|---|
| 14 | 1 | l-Ala | CH2tBu | 0.05 | 73 |
| 15 | 1 | d-Ala | CH2tBu | 0.23 | >100 |
| 7 | 4′-AzU | – | – | >100, Ref. [21] | >100, Ref. [21] |
| 26 | 4′-AzU | l-Ala | Bn | >40 | >100 |
| 27 | 4′-AzU | l-Ala | CH2tBu | 22 ± 7 | >100 |
| 8 | 4′-AzC | – | – | 7.13, Ref. [22] | >100, Ref. [22] |
| 28 | 4′-AzC | l-Ala | Bn | >40 | >100 |
| 29 | 4′-AzC | l-Ala | CH2tBu | >40 | 72 |
| 9 | RBV | – | – | 87, Ref. [23] | >100, Ref. [23] |
| 30 | RBV | l-Ala | Bn | >100 | >100 |
| 31 | RBV | l-Ala | CH2tBu | >100 | >100 |
| 10 | ACV | – | – | 30, Ref. [24] | >30, Ref. [24] |
| 32 | ACV | l-Ala | Bn | >100 | – |
| 33 | ACV | l-Ala | CH2tBu | >100 | – |