Table 4.
Antiviral activity of test compounds against herpes simplex virus type 1 and 2 and feline herpes virus and cytotoxicity (MCC) in HEL and CrFK cell cultures.
| Compd | Nucleoside | AA | R | MCC (μM) | EC50 (μM) HEL cell |
|||
|---|---|---|---|---|---|---|---|---|
| Herpes simplex virus 1(KOS) | Herpes simplex virus 2 (G) | Herpes simplex virus 1TK−(KOS)ACVr | Feline herpes virus | |||||
| 13 | AICA | – | – | >100 | >100 | >100 | >100 | >100 |
| 38 | AICA | l-Ala | Bn | >100 | >100 | >100 | >100 | >100 |
| 39 | AICA | l-Ala | Me | >100 | >100 | >100 | >100 | >100 |
| 40 | AICA | l-Ala | CH2tBu | >100 | >100 | >100 | >100 | >100 |
| 10 | ACV | – | – | >100 | 0.23 ± 0.20 | 0.2 ± 0 | 23 ± 5 | >100 |
| 32 | ACV | l-Ala | Bn | >100 | 18 ± 14 | 16 ± 19 | 25 ± 22 | >100 |
| 33 | ACV | l-Ala | CH2tBu | >100 | 33 ± 18 | 40 ± 8 | 20 ± 0 | >100 |
| 12 | Cf1743 | – | – | ≥20 | >20 | >20 | >20 | >100 |
| 36 | Cf1743 | l-Ala | Bn | >100 | >100 | >100 | >100 | >100 |