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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824

Fig. 1. Pharmacological inhibition of Panx1 reduces vasoconstriction and ATP release selectively upon activation of α1AR.

Fig. 1

(A to D) Effect of 10Panx1 (300 μM) and probenecid (2 mM) on contractile response of pressurized TDAs stimulated with the indicated concentrations of agonists. n = 5to7. *P < 0.05 compared to untreated response (black curves) using two-way analysis of variance (ANOVA). (E) Relative ATP released from intact TDAs in response to phenylephrine (PE) in the presence or absence of 10Panx1 (300 μM), serotonin (5-HT), or endothelin-1 (ET-1). Data are presented as a percent increase in ATP concentration from unstimulated conditions. The insert shows an image of a TDA in a well of a 96-well dish. n = 5 to 11. *P < 0.05 compared to phenylephrine using a Kruskal-Wallis test.