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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: Bone. 2013 Dec 4;59:229–234. doi: 10.1016/j.bone.2013.11.026

Figure 1.

Figure 1

(a) Sinusoidal loading was applied non-invasively to the rat lower hindlimb, which was constrained between a custom-made knee cup and foot holder. The lower limb was compressed in the direction indicated by the arrows. (b) Strain-gage calibration of the loading device using control rats (n=3; each rat represented by a symbol, ● ▲ ◆) illustrates the relationship between applied load (N) and measured deformation (microstrain) of the proximal tibia. After tracer injection, an applied load of 14 N, which engenders ~500 microstrain at the medial proximal diaphysis, was applied at 1 Hz to mimic slow walking.