Table 1.
Patient characteristics at the time of diagnosis
| IPAH (n = 99) | PH-HFpEF (n = 86) | p-value | |
|---|---|---|---|
| Age (years) | 47 ± 17 | 69 ± 10 | <0.001 |
| Female (%) | 74 | 64 | 0.101 |
| Body mass index (kg/m2) | 26 ± 5 | 30 ± 6 | <0.001 |
| Diabetes (%) | 19 | 57 | <0.001 |
| NYHA II/III/IV (n) | 38/60/1 | 8/77/1 | n/a |
| 6 min walking distance (m) | 386 ± 136 | 276 ± 117 | <0.001 |
| Right atrial pressure (mmHg) | 7 ± 5 | 13 ± 5 | <0.001 |
| PAPm (mmHg) | 53 ± 12 | 47 ± 10 | <0.001 |
| PAWP (mmHg) | 8 ± 3 | 21 ± 5 | <0.001 |
| Transpulmonary gradient (mmHg) | 46 ± 13 | 25 ± 10 | <0.001 |
| Diastolic gradient (mmHg) | 24 ± 11 | 10 ± 8 | <0.001 |
| CO (L/min) | 3.9 ± 1.2 | 4.9 ± 1.3 | <0.001 |
| CI (L/min/m2) | 2.1 ± 0.6 | 2.5 ± 0.7 | <0.001 |
| PVR (dyn · s · cm−5) | 1,017 ± 416 | 471 ± 218 | <0.001 |
| SvO2 (%) | 64 ± 9 | 63 ± 8 | 0.368 |
| PcaO2 (kPa) | 9.5 ± 1.5 | 8.7 ± 1.2 | 0.039 |
| PcaO2 (mmHg) | 71 ± 11 | 65 ± 9 | |
| PcaCO2 (kPa) | 4.4 ± 0.5 | 5.3 ± 0.7 | <0.001 |
| PcaCO2 (mmHg) | 33 ± 4 | 40 ± 5 |