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. 2015 Feb 21;13:67. doi: 10.1186/s12967-015-0422-3

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© Lu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ASC-CM suppresses ICAM-1 and E-selectin expression by HPAEC. HPAEC were treated with vehicle control (NoPr, black bars), NHDF-CM (DF-CM, grey bars), and hASC-CM (ASC-CM, white bars), and then stimulated with vehicle or 1 ng/ml TNFα (4 h). Harvested cells were analyzed for the surface expression of ICAM-1 and E-selectin. Experiments with independent treatment/stimulation were repeated in triplicate. T-test was used to assess the differences between analyzed groups. Exposure to hASC-CM lowers the percentage of ICAM-1-expressing quiescent HPAEC and reduces the level of E-selectin expression in TNFα-stimulated HPAEC.