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. 2015 Feb 21;13:67. doi: 10.1186/s12967-015-0422-3

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© Lu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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hASC-CM preserves microscopic HPAEC monolayer integrity. Preincubation of endothelial monolayers with hASC-CM suppressed H₂O₂-induced rearrangement of F-actin cytoskeleton and disintegration of peripheral adherens junctions. Arrows indicate the gaps appeared in previously intact monolayer in response to H₂O₂.