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. 2015 Mar 13;11(3):e1004757. doi: 10.1371/journal.ppat.1004757

Fig 5. Th2-associated immune response is necessary for lung pathology and airway hyperreactivity.

Fig 5

(A) Mock- or FI-RSV-immunized WT and STAT6-deficient mice were assessed daily for airway obstruction and weight loss following RSV challenge. (B) H&E and PAS staining on lung sections from immunized WT and STAT6 KO mice was performed on day 4 following RSV infection. Representative pictures for each group were taken at 200X magnification. (C) Stained lung sections were scored for degree of PVA, mucus, and total histopathology score. (D) Airway resistance and compliance in vaccinated WT or STAT6-deficient mice was evaluated on day 4 post-infection. Data are represented as mean ± SEM of two independent experiments (n = 12 mice total for A, n = 8 total mice for B-D). Groups were compared using one-way ANOVA at each time point, * p<0.05, ** p<0.01, *** p<0.001.