Table 5.

Descriptive summary of serum azithromycin and plasma chloroquine/desethylchloroquine concentrations

Study day	Time post dose (hrs)
		Mean (% CV) azithromycin serum concentrations*
		Cohort 1	Cohort 2	Cohorts 1 and 2 combined
0	0	0 N = 52	0 N = 119	0 N = 171
2	0	216 (39) N = 49	195 (93) N = 114	201 (78) N = 163
2	3	1160 (44) N = 49	906 (58) N = 111	938 (54) N = 160
2	8	609 (48) N = 49	467 (59) N = 115	510 (56) N = 166
7	NS	44.7 (67) N = 48	26.9 (75) N = 118	320 (77) N = 166
		Mean (% CV) chloroquine plasma concentrations*
0	0	0 N = 44	0 N = 107	0 N = 151
2	0	172 (35) N = 49	131 (53) N = 110	144 (48) N = 159
2	3	430 (36) N = 48	331 (44) N = 107	362 (43) N = 155
2	8	367 (43) N = 49	295 (40) N = 106	318 (43) N = 155
7	NS	54.5 (67) N = 49	35.1 (53) N = 112	41.0 (65) N = 166
		Mean (% CV) desethylchloroquine plasma concentrations*
0	0	0 N = 43	0 N = 103	0 N = 146
2	0	95.1 (77) N = 49	77.5 (67) N = 110	82.9 (72) N = 159
2	3	170 (48) N = 49	138 (48) N = 107	148 (49) N = 156
2	8	160 (58) N = 49	147 (58) N = 104	151 (58) N = 153
7	NS	66.9 (94) N = 49	38.5 (87) N = 112	46.8 (97) N = 161

*Concentration is in ng/mL.

CV = coefficient of variation, NS = not specified.