Table 2. Pearson’s correlation coefficient and Mander’s overlap colocalization coefficients of quantitative confocal analysis.
| Coefficients | Normal | Asthmatic | COPD | P |
|---|---|---|---|---|
| Cell membrane marker and vitronectin (Rp) | 0.54 (0.44–0.59) | 0.71 (0.62–0.80) | 0.67 (0.61–0.75) | 0.0471 a |
| Cell membrane marker (Mx) b | 0.79 (0.71–0.85) | 0.87 (0.80–0.93) | 0.95 (0.88–0.96) | 0.0830 |
| Vitronectin (My) b | 0.76 (0.66–0.80) | 0.90 (0.87–0.94) | 0.85 (0.84–0.97) | 0.0471 a |
| Lactoferrin and vitronectin (Rp) | 0.72 (0.67–0.78) | 0.47 (0.44–0.53) | 0.55 (0.50–0.59) | < 0.0001 a |
| Lactoferrin (Mx) c | 0.83 (0.77–0.88) | 0.73 (0.62–0.78) | 0.63 (0.59–0.68) | 0.0017 a |
| Vitronectin (My) c | 0.96 (0.93–0.97) | 0.92 (0.90–0.93) | 0.90 (0.85–0.93) | 0.0040 a |
| MUC5B and vitronectin (Rp) | 0.40 (0.17–0.48) | 0.08 (0.05–0.16) | 0.05 (0.03–0.06) | 0.0018 a |
| MUC5B (Mx) d | 0.54 (0.18–0.62) | 0.11 (0.06–0.23) | 0.14 (0.10–0.17) | 0.0031 a |
| Vitronectin (My) d | 0.54 (0.44–0.59) | 0.71 (0.62–0.80) | 0.67 (0.61–0.75) | < 0.0001 a |
| MUC5AC and vitronectin (Rp) | 0.79 (0.71–0.85) | 0.87 (0.80–0.93) | 0.95 (0.88–0.96) | 0.4724 |
| MUC5AC (Mx) e | 0.76 (0.66–0.80) | 0.90 (0.87–0.94) | 0.85 (0.84–0.97) | 0.1910 |
| Vitronectin (My) e | 0.72 (0.67–0.78) | 0.47 (0.44–0.53) | 0.55 (0.50–0.59) | 0.0550 |
Values are expressed as medians (interquartile ranges). Rp, Pearson’s correlation coefficient; Mx, Mander’s colocalization coefficient for channel 1; My, Mander’s colocalization coefficient for channel 2.
a Statistically significant values by Kruskall-Wallis H test.
b,c,d,e Mander's overlap coefficients for colocalization analysis of cell membrane marker/vitronectin (b), lactoferrina/vitronectin (c), MUC5B/vitronectin (d), and MUC5AC/vitronectin (e).