Fig 2. IFNγ administration rescues survival of Il-18 ^-/-, but not Il-1r1 ^-/-, mice intranasally infected with Ft LVS.

(A) Cytokine levels were measured 72 hours or 6 days p.i. in BALF (A) or serum (B) of mice intranasally infected with 4x10³ CFU Ft LVS. (C) Mice (n = 5), of shown genotypes, were intranasally infected with 4x10³ CFU Ft LVS and recombinant IFNγ (1 μg) was administered daily by i.p. injection for the first 6 days. Survival was monitored. One representative experiment of two is shown. Data are expressed as mean + S.D. *p<0.05, **p<0.01. Mann-Whitney U test.