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. Author manuscript; available in PMC: 2016 Jan 13.
Published in final edited form as: Cell Rep. 2015 Jan 8;10(2):280–291. doi: 10.1016/j.celrep.2014.12.025

Figure 7. Reciprocal regulation of memory NK cell progenitors by commensal bacteria and T cells – a hypothetical model.

Figure 7

Nod receptors on host non-hematopoietic cells sense commensal bacteria and enhance IL-15 production in myeloid cells. Competitive consumption of IL-15 by T cells inhibits the induction of KLRG1int+ NK cells and preserves progenitor KLRG1− NK cells that preferentially develop into KLRG1high memory NK cells.