Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Hypertension. 2015 Feb 17;65(4):800–805. doi: 10.1161/HYPERTENSIONAHA.115.05166

Figure 5. Deletion of Cys18-Cys137 disulfide bond of AGT did not affect systolic blood pressure or atherosclerosis.

Figure 5

(A) Systolic blood pressures were measured using a non-invasive tail-cuff system 8 weeks after AAV injection. N = 4 – 6/group. * denotes P ≤ 0.01 versus the other 3 groups by one way ANOVA with Holm-Sidak method. (B) Atherosclerotic lesion areas were measured on the intimal surface of the aortic arch region using an en face method. Percent lesion area = lesion area/the entire intimal area × 100%. Triangles represent values of individual mice (N = 8 – 11/group), circles represent means, and error bars are SEM. * denotes P < 0.001 versus the other 3 groups by one way ANOVA with Holm-Sidak method. WT represents wild-type AGT AAV, and C18S,C137S represents AGT in AAV vector with Cys to Ser mutations at 18 and 137 residues.