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. 2015 Mar 13;10(3):e0120071. doi: 10.1371/journal.pone.0120071

Fig 2. Peritoneal ovarian cancer growth is reduced in LPP1 KO mice.

Fig 2

Following IP injection of ID8ip2Luc cells, mice were imaged weekly to monitor tumor growth kinetically. (A) Representative luminescence images of wild type and LPP1 KO mice with tumor taken at 2-week intervals. (B) Quantification of total flux (photons/second) was determined weekly for wild type (n = 10) and LPP1 KO (n = 12) mice. Data represent mean ± std err; p < 0.001 determined by 2-way ANOVA followed by Tukey’s multiple comparisons test. (C) Data represent the number of macroscopic tumor nodules per mouse determined 8 weeks after tumor initiation. Mice with too many nodules to count were assigned a value of 200. Data represent median with 25th and 75th percentiles; p = 0.02 determined using the Wilcoxan-Mann-Whitney test. (D) Tumor volume was determined by weighing the omentum (primary site of tumor formation) and all associated tumor nodules 8 weeks after tumor initiation; each point indicates an individual mouse. Data represent median with 25th and 75th percentiles; p = 0.0031 determined by Student’s t-test.