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Localization of BGN mRNA in CADASIL and control brain vessels. In situ hybridization was performed on frontal cortex of genetically-defined CADASIL brains (A and B) and controls (C). Small penetrating arteries (A and C) and leptomeningeal vessels (B) are shown. Magnification is at 400x. (D) Quantitative RT-PCR analysis of BGN mRNA from controls and CADASIL brains are shown; differences were significant with p<0.05.
