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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Hypertension. 2015 Feb 17;65(4):916–923. doi: 10.1161/HYPERTENSIONAHA.114.05075

Figure 1. NE-induced hypertension suppresses splenic T-lymphocyte activation.

Figure 1

Mice were infused with saline or NE (3.8 µg/kg/min) for 14 days. A. Urine and plasma NE levels 14 days after saline or NE infusion. N=5. B. Mean arterial pressure (MAP) and heart rate (HR) during 14 days of saline or NE infusion. Arrow indicates start of NE infusion. N=8. C. T-lymphocyte numbers at 0–48 hours of ex vivo culture with CD3 stimulation. T-lymphocytes were isolated on day 14 after the start of saline or NE infusion, and plated for 48 hours with CD3 stimulation. N=4. D. IFNγ and TNFα levels in media at 0–48 hours of T-lymphocyte ex vivo culture. ND indicates non-detectable. N=4. *p<0.05 vs. saline-infused.